What each tool actually does
MasterControl runs the quality operations of large pharma and medtech — document control, validated training, manufacturing execution, electronic signatures. It is robust, heavy, and priced accordingly. Regfo is not a QMS. It reads your preclinical studies and checks them against the specific ICH/FDA rules that matter for Phase 1 through NDA. Different problems, different tools.
Regfo
Answers "what gaps does my IND package have?" in 30 seconds.
MasterControl
Answers "how do we run validated quality at pharma scale?"
Price and time horizon
MasterControl is quote-only and comes with multi-quarter implementations. Third-party estimates put entry around $25K/yr, commonly scaling past $100K once you add modules, seats, and validation services — treat those as estimates, not official prices. That cost is correct when you are scaling a GxP manufacturing site. It is wrong when you are one IND away from Phase 1 and need to answer a compliance question this week. Regfo was built for that second situation — fast to onboard, priced for emerging biotech budgets.
Regfo
Free ($0), Pro ($399/mo), Team ($999/mo). 20% off annual. No setup fees, no implementation contracts.
MasterControl
Quote-only; third-party estimates from ~$25K/yr scaling past $100K, plus implementation and validation.
Regulatory depth on IND work
MasterControl supports regulatory submissions as part of a broader quality suite. Regfo treats IND readiness as the core product. When a finding comes back, it links to "ICH M3(R2) §2.3" rather than to a generic compliance control. For a regulatory team in crunch mode, that link is worth the rest of the feature list.
Regfo
24 ICH guidelines parsed, 1,054 rules enforced.
MasterControl
Regulatory modules exist — but the core value is quality management.